NFL Injury Updates: Which Stars Might Miss the Opener?

By Jason Bolton June 29, 2025 14:10

As the 2025 NFL season approaches, several star players face uncertain statuses due to lingering injuries, raising questions about who might miss the crucial Week 1 openers. Teams are carefully monitoring their key athletes’ recovery progress, balancing the desire to start strong with the long-term health of their rosters.

High-Profile Injury Concerns Heading Into Week 1

One of the most closely watched situations involves wide receiver Michael Gallup of the Washington Commanders. Gallup is currently listed as questionable with a hamstring injury ahead of their opener against the New York Giants. Given the importance of his role in the passing game, Commanders head coach emphasized, “We’re hopeful Mike can get back on the field, but we won’t rush him. His health comes first”.

Similarly, the San Francisco 49ers face multiple injury questions. Nick Martin, their starting linebacker, is officially out for Week 1 due to a lower-body injury, while quarterback Kurtis Rourke is questionable with a knee issue. Wide receiver Ricky Pearsall and safety Ji’Ayir Brown are also listed as questionable, which could impact the 49ers’ early-season chemistry against the Seattle Seahawks.

The Seattle Seahawks have their own injury concerns, with running back Kenneth Walker III questionable due to an ankle injury. Defensive players Byron Murphy II and Ernest Jones are also listed as questionable, potentially affecting both sides of the ball in their opener against San Francisco.

Notable Absences Confirmed

Some players will definitely miss Week 1 action. Panthers rookie running back Jonathon Brooks remains on the Physically Unable to Perform (PUP) list as he continues recovering from a second ACL tear suffered last season, ruling him out for the entire 2025 campaign. For the Commanders, linebacker Ale Kaho is out for Week 1 with an undisclosed injury.

Monitoring Stars with Lingering Issues

While some injuries are well-known, others remain under close watch. Eagles star wide receiver DeVonta Smith, who battled a hamstring issue late last season, was limited in recent practices but is expected to be ready for the start of the season. Eagles quarterback Jalen Hurts, who missed time due to concussion protocol during the playoffs, has reportedly recovered and is preparing to lead Philadelphia’s offense.

Kansas City Chiefs receiver Skyy Moore, sidelined since Week 6 with an abdominal injury, is listed as doubtful for the opener. The Chiefs must decide whether to activate him off injured reserve by the Saturday deadline, but the odds currently favor a delayed return.

Impact on Team Strategies

These injury uncertainties will force teams to adjust their Week 1 game plans. The 49ers, for example, may need to rely more heavily on their running game and depth receivers if key starters remain sidelined. The Commanders’ offensive scheme could be limited without Gallup at full strength, placing additional pressure on quarterback Sam Hartman and emerging targets.

NFL analyst Mike Florio noted, “Early-season injuries to key players can disrupt team rhythm, but smart coaching staffs use this time to evaluate depth and build resilience. The teams that manage these challenges well often set the tone for their entire season.”

Heading into the 2025 NFL opener, injury reports reveal a mix of hopeful returns and confirmed absences among star players. While some teams like the Eagles and Chiefs appear poised to field near-full strength lineups, others such as the 49ers and Commanders face significant questions. As the countdown to kickoff continues, all eyes will be on medical updates and final decisions that could shape the opening weekend and beyond.

In the unpredictable world of NFL injuries, the ability to adapt quickly remains as crucial as ever for teams aiming to start the season on a winning note.